Dynamics of the fecal microbiome in patients with recurrent and nonrecurrent Clostridium difficile infection

Microbiota Dynamics in Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

Clostridium difficile causes antibiotic-associated diarrhea and pseudomembraneous colitis and is responsible for a large and increasing fraction of hospital-acquired infections. Fecal microbiota transplantation (FMT) is an alternate treatment option for recurrent C. difficile infection (RCDI) refractory to antibiotic therapy. It has recently been discussed favorably in the clinical and scientif...

Correction: Microbiota Dynamics in Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

71Alterations in the Gut Microbiome in Recurrent Clostridium difficile Infection

Background. Clostridium difficile infection (CDI) causes 3 million cases of diarrhea and colitis in the US annually. Although standard antibiotic is effective in suppressing C. difficile, it does not prevent relapse. Indeed, 15 to 30% of patients experience recurrence within 3 months following antibiotic treatment. Recovery of the gut microbiota has been proposed as an important key factor in p...

Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis

BACKGROUND Studies of colonoscopic fecal microbiota transplant (FMT) in patients with recurrent CDI, indicate that this is a very effective treatment for preventing further relapses. In order to provide this service at Stony Brook University Hospital, we initiated an open-label prospective study of single colonoscopic FMT among patients with ≥ 2 recurrences of CDI, with the intention of monitor...

Engraftment and Augmentation of Microbiome Following Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection